Vicissitudes in Lipid Peroxidation and Antioxidants in Elderly Niddm Patients

Advanced age in type-II diabetic patients is associated with an accumulation of free radical damage, which leads to physiological and\ clinical modifications. Age related changes resulting from free radical reactions include increasing levels of lipid peroxides, alterations in enzyme activities and greater osmotic fragility. The present study was conducted to estimate the level of lipid peroxidation product – Malondialdehyde and antioxidants Catalase and Glutathione in elderly people with Non Insulin Dependent Diabetes Mellitus. An increase in lipid peroxidation and decrease in antioxidants was observed in these people. Highly significant increase in MDA and decrease in antioxidants was observed. When complicated with diabetes and hypertension. Supplementation of antioxidants may prevent further oxidative injury in these patients. KeywordsLipid peroxidation, Antioxidants, NIDDM elderly